Senior Research Associate, Antibody Discovery

Mountain View, CA  |  Full time

Job Description

AbTherx is seeking a highly motivated and experienced individual to join our Antibody Discovery team as a Senior Research Associate. The successful candidate will contribute to our efforts toward the discovery of monoclonal antibodies using hybridoma and single B cell technologies from AbTherx AtlasTM mice. The successful candidate will be expected to work independently to oversee and deliver on projects against a variety of targets.

About AbTherx

Founded in 2023 through a unique partnership with Gilead Sciences, AbTherx is a privately held biotech company advancing medicine with novel technologies that accelerate and enable therapeutic antibody discovery. Our team’s experience includes multiple successful biotech ventures, leading antibody discovery in global pharma, and the development of the most successful human antibody discovery platform with 13 marketed therapeutics. Through technology licensing and research collaborations, AbTherx partners with drug developers of all sizes to overcome the most demanding challenges in delivering innovative medicines.

Key Responsibilities

  • Design and execute antibody discovery campaigns to generate monoclonal antibodies using hybridoma and/or B cell technology platforms.
  • Immunize mice—wt and Atlas™ Mice—using both standard and innovative techniques, targeting both spleen and lymph nodes.
  • Evaluate serum titers, harvest spleen and lymph nodes, and perform electro-fusions and subcloning.
  • Screen and characterize antibodies for binding and functional activity using ELISA, flow cytometry, biochemical and cell-based assays, and biomolecular interaction technologies such as SPR or BLI.
  • Maintain, expand, cryopreserve, and clone hybridoma cell lines.
  • Perform small-scale antibody expression and purification.
  • Explore new technologies, opportunities, and automation to improve and/or streamline the antibody discovery workflows and processes.
  • Maintain accurate registering of experimental results and sample tracking, and provide regular progress updates.

Qualification Requirements

  • MS in molecular biology, biochemistry, immunology, or related field with 5+ years of industry experience, or BS with 8+ years of industry experience with strong success track record.
  • Hands-on experience with antibody discovery using hybridoma technology and/or single B cell approach is a must.
  • Small animal handling techniques are a must.
  • Hands-on experience with cell biology including mammalian cell culture, transfection, and running functional cell-based assays.
  • Hands-on experience with protein-protein interaction using a variety of methods such as ELISA, flow cytometry, bio-layer interferometry (Octet).
  • Experience with automation and high throughput assay development is highly desirable.
  • Experience with molecular biology techniques is desirable.
  • Ability to work independently and as part of a team in a startup environment.
  • We are looking for a highly organized and energetic person with excellent attention to detail, time management, and communication skills.

Why Join AbTherx?

At AbTherx, we’re driven to create new medicines that improve human health. We are passionate about our platform’s ability to positively impact the future of medicine and recognize the vital role our team plays in shaping our science and culture.

We support our employees by providing a competitive total compensation package, including stock options, an annual performance bonus incentive program, a comprehensive benefits package, paid time off, two one-week company shutdowns each year in the summer and winter, and opportunities for professional development. We regularly hold company-wide meetings to foster open communication and a supportive community.

Join us in our dynamic startup environment where you’ll partner with colleagues of diverse backgrounds and abilities, people who contribute to all aspects of what makes our platform powerful—from technology development to drug discovery to business operations, and so much more.

AbTherx is an Equal Opportunity Employer and committed to creating an inclusive environment for all employees. We do not discriminate on the basis of race, color, religion, age, sex, creed, national origin, ancestry, citizenship status, marital or domestic or civil union status, familial status, affectional or sexual orientation, gender identity or expression, genetics, disability, military eligibility or veteran status, or any other protected status.

Primary Work Location

Mountain View, CA

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